Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 160 391.75 97.52 60,385,952
Mutual Fund 311 134.58 27.51 16,940,163
Insider 7 16.37 2.27 1,406,371

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 74 82.58 19.70 12,195,636
Sellers 93 -57.86 14.99 -9,283,868
Net 24.72 4.70 2,911,768

Concentration

Value ($MM) % O/S Shares
Total Inst. 479.63 112.12 69,423,590
Top 10 Inst. 333.57 76.82 47,567,981
Top 20 Inst. 413.50 96.35 59,662,903
Top 50 Inst. 465.74 108.72 67,319,183

Style

Holders Value ($MM) % Inst Shares Shares
Growth 38 33.64 8.99 5,563,940
Aggressive Growth 3 0.29 0.08 48,690
Core Growth 29 13.39 3.56 2,205,908
Growth 6 19.96 5.34 3,309,342
Income 2 0.98 0.26 159,208
Income Value 1 0.90 0.24 149,858
Yield 1 0.08 0.02 9,350
Index 23 63.09 16.97 10,509,989
Other 53 223.79 53.12 32,889,185
Broker Dealer 13 2.51 0.68 419,395
GARP 12 34.98 8.62 5,340,457
Hedge Fund 27 167.44 38.73 23,980,858
Specialty -- --
Sector Specific 1 18.86 5.08 3,148,475
Value 21 60.80 16.23 10,048,588
Core Value 18 56.44 15.05 9,321,030
Deep Value 3 4.36 1.18 727,558

Location: Global Region

Holders % O/S Shares Share Value
North America 133 93.92 58,158,396 383,235,216
Europe 28 17.96 11,119,375 95,530,916
Asia / Pacific 6 0.23 144,381 853,704
Latin America 1 -- 1,438 8,614

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 8,438,412 13.63 1,053 6/30/19
Chione, Ltd. 7,631,267 12.32 -761,872 12/31/18
Consonance Capital Management LP 5,803,227 9.37 644,343 6/30/19
Palo Alto Investors LP 5,262,263 8.50 -- 6/30/19
BlackRock Institutional Trust Company, N.A. 4,131,076 6.67 359,911 6/30/19
Ridgeback Capital Management, L.P. 3,945,200 6.37 1,213,075 12/31/18
Millennium Management LLC 3,372,566 5.45 3,299,911 7/22/19
OrbiMed Advisors, LLC 3,148,475 5.08 2,436,875 6/30/19
The Vanguard Group, Inc. 2,983,862 4.82 369,590 6/30/19
Emerald Advisers LLC 2,851,633 4.61 -32,936 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,750,506 2.83 -- 8/31/19
iShares Russell 2000 ETF 1,185,417 1.91 -58,912 8/31/19
Biotech Growth Trust PLC 1,082,100 1.75 370,500 6/30/19
Fidelity Select Biotechnology Portfolio 969,100 1.57 -79,000 7/31/19
Candriam Equities L Biotechnology 950,950 1.54 -864,550 7/31/19
Wellington Global Healthcare Equity Fund 879,921 1.42 112,921 6/30/19
Emerald Growth Fund 833,486 1.35 -- 7/31/19
Vanguard Extended Market Index Fund 729,095 1.18 13,257 8/31/19
iShares NASDAQ Biotechnology ETF 589,219 0.95 -15,610 8/31/19
iShares Russell 2000 Growth ETF 532,480 0.86 -3,504 8/31/19

* Insider values reflect direct beneficial ownership.

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