Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 166 391.12 99.75 60,713,661
Mutual Fund 312 106.19 29.57 17,698,621
Insider 7 12.13 2.23 1,356,746

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 73 78.52 20.83 12,679,773
Sellers 86 -66.06 17.56 -10,689,890
Net 12.47 3.27 1,989,883

Concentration

Value ($MM) % O/S Shares
Total Inst. 474.75 114.52 69,701,674
Top 10 Inst. 318.99 73.42 44,687,699
Top 20 Inst. 393.67 93.87 57,131,819
Top 50 Inst. 456.20 109.98 66,939,446

Style

Holders Value ($MM) % Inst Shares Shares
Growth 38 40.29 11.11 6,760,353
Aggressive Growth 1 -- -- 579
Core Growth 29 19.12 5.34 3,251,043
Growth 8 21.17 5.76 3,508,731
Income 3 1.06 0.30 182,665
Income Value 2 1.01 0.28 173,315
Yield 1 0.04 0.02 9,350
Index 22 54.78 15.43 9,390,028
Other 58 191.89 49.77 30,292,265
Broker Dealer 14 2.18 0.61 373,132
GARP 13 40.67 11.43 6,954,812
Hedge Fund 31 149.04 37.73 22,964,321
Specialty -- -- -- --
Value 20 60.29 16.71 10,172,960
Core Value 17 56.37 15.61 9,502,751
Deep Value 3 3.91 1.10 670,209

Location: Global Region

Holders % O/S Shares Share Value
North America 136 93.95 57,181,229 372,412,400
Europe 30 20.34 12,380,829 101,098,084
Asia / Pacific 7 0.23 136,971 1,228,606
Latin America 1 -- 2,645 15,447
Middle East -- -- -- --

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 8,437,359 13.86 220,578 3/31/19
Chione, Ltd. 7,631,267 12.54 -761,872 12/31/18
Palo Alto Investors LP 5,262,263 8.65 576,911 3/31/19
Consonance Capital Management LP 5,158,884 8.48 348,806 3/31/19
Ridgeback Capital Management, L.P. 3,945,200 6.48 1,213,075 12/31/18
BlackRock Institutional Trust Company, N.A. 3,771,165 6.20 -86,697 3/31/19
Emerald Advisers LLC 2,884,569 4.74 54,659 3/31/19
Millennium Management LLC 2,719,714 4.47 2,272,107 3/31/19
The Vanguard Group, Inc. 2,614,272 4.30 885,385 3/31/19
Pakianathan (Deepika R) 2,263,006 3.72 2,263,006 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Candriam Equities L Biotechnology 1,815,500 2.98 -- 3/31/19
Vanguard Total Stock Market Index Fund 1,750,506 2.88 381,040 4/30/19
Fidelity Select Biotechnology Portfolio 1,533,800 2.52 -- 3/31/19
iShares Russell 2000 ETF 1,029,864 1.69 -38,178 4/30/19
Emerald Growth Fund 833,486 1.37 -- 2/28/19
Wellington Global Healthcare Equity Fund 767,000 1.26 285,167 12/31/17
Vanguard Extended Market Index Fund 708,054 1.16 1,125 4/30/19
iShares NASDAQ Biotechnology ETF 628,227 1.03 -3,520 4/30/19
Hartford Healthcare Fund 457,189 0.75 -- 3/31/19
PZU FIO Energia Medycyna Ekologia 424,134 0.70 -63,997 12/31/17

* Insider values reflect direct beneficial ownership.

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