Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 202 1,405.15 100.17 73,221,138
Mutual Fund 208 233.26 17.21 12,255,836
Insider 8 28.81 1.95 1,421,947

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 111 367.03 26.12 19,098,609
Sellers 109 -230.53 16.44 -12,021,276
Net 136.50 9.68 7,077,333

Concentration

Value ($MM) % O/S Shares
Total Inst. 1,545.19 110.09 80,431,122
Top 10 Inst. 854.40 60.91 44,488,685
Top 20 Inst. 1,185.61 84.52 61,734,720
Top 50 Inst. 1,462.28 104.08 76,040,279

Style

Holders Value ($MM) % Inst Shares Shares
Growth 51 208.49 14.84 10,850,129
Aggressive Growth 3 3.38 0.24 176,062
Core Growth 37 153.54 10.93 7,989,214
Growth 11 51.58 3.67 2,684,853
Income 3 3.47 0.25 181,932
Income Value 1 3.31 0.24 172,217
Yield 2 0.16 0.01 9,715
Index 26 263.18 18.74 13,701,671
Other 64 820.22 58.40 42,699,171
Broker Dealer 13 24.20 1.72 1,259,780
GARP 20 115.68 8.24 6,023,365
Hedge Fund 28 501.81 35.73 26,122,511
Specialty 1 0.59 0.04 30,509
VC Private Equity 2 177.94 12.67 9,263,006
Sector Specific -- -- -- --
Value 22 36.93 2.69 1,965,403
Core Value 17 31.97 2.34 1,707,831
Deep Value 5 4.96 0.35 257,572

Location: Global Region

Holders % O/S Shares Share Value
North America 171 94.80 69,293,653 1,331,451,242
Europe 30 14.31 10,422,009 199,765,711
Middle East 1 0.75 550,000 10,565,500
Asia / Pacific 9 0.10 72,922 1,368,611

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Consonance Capital Management LP 7,180,700 9.82 1,053,266 3/31/20
Avoro Capital Advisors LLC 7,000,000 9.57 1,100,000 3/31/20
Chione, Ltd. 5,695,499 7.85 -1,935,768 12/31/19
BlackRock Institutional Trust Company, N.A. 4,436,499 6.07 67,417 3/31/20
Palo Alto Investors LP 4,299,901 5.88 -295,100 3/31/20
Adage Capital Management, L.P. 3,723,532 5.09 -63,468 3/31/20
Janus Henderson Investors 3,252,828 4.45 3,246,852 3/31/20
The Vanguard Group, Inc. 3,248,459 4.44 482,568 3/31/20
State Street Global Advisors (US) 3,247,487 4.44 19,121 3/31/20
D. E. Shaw & Co., L.P. 2,403,780 3.29 38,269 3/31/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 1,818,761 2.49 -221,443 4/30/20
Vanguard Total Stock Market Index Fund 1,784,820 2.44 231,328 3/31/20
iShares Russell 2000 ETF 1,286,908 1.76 -41,996 4/30/20
Janus Henderson Global Life Sciences Fund (US) 1,190,843 1.63 1,190,843 3/31/20
Vanguard Extended Market Index Fund 903,456 1.24 128,478 3/31/20
Fidelity Select Biotechnology Portfolio 769,298 1.05 137,500 3/31/20
Janus Henderson Global Life Sciences Fund (Ire) 740,160 1.01 740,160 3/31/20
iShares NASDAQ Biotechnology ETF 614,225 0.84 74,096 4/30/20
iShares Russell 2000 Growth ETF 519,828 0.71 1,217 4/30/20
Emerald Growth Fund 508,178 0.70 216,165 3/31/20

* Insider values reflect direct beneficial ownership.

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