Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 164 356.22 95.29 57,999,501
Mutual Fund 306 103.80 27.70 16,666,738
Insider 7 8.17 2.26 1,376,479

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 74 78.93 20.95 12,752,161
Sellers 87 -70.62 18.43 -11,216,260
Net 8.31 2.52 1,535,901

Concentration

Value ($MM) % O/S Shares
Total Inst. 435.90 110.09 67,007,167
Top 10 Inst. 299.44 72.85 44,341,471
Top 20 Inst. 365.24 91.36 55,608,635
Top 50 Inst. 420.43 105.99 64,511,420

Style

Holders Value ($MM) % Inst Shares Shares
Growth 37 40.22 11.09 6,751,423
Aggressive Growth 1 -- -- 579
Core Growth 28 19.05 5.33 3,242,113
Growth 8 21.17 5.76 3,508,731
Income 3 1.07 0.30 182,665
Income Value 2 1.01 0.28 173,315
Yield 1 0.06 0.02 9,350
Index 22 54.73 15.40 9,373,108
Other 58 191.80 49.85 30,342,265
Broker Dealer 14 2.18 0.61 373,132
GARP 13 40.58 11.51 7,004,812
Hedge Fund 31 149.04 37.73 22,964,321
Specialty -- --
Value 20 60.28 16.71 10,173,124
Core Value 17 56.36 15.61 9,502,915
Deep Value 3 3.91 1.10 670,209

Location: Global Region

Holders % O/S Shares Share Value
North America 136 90.28 54,950,359 338,420,013
Europe 28 19.58 11,917,113 96,247,131
Asia / Pacific 7 0.23 137,130 1,217,419
Latin America 1 -- 2,645 15,447

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 8,437,359 13.86 220,578 3/31/19
Chione, Ltd. 7,631,267 12.54 -761,872 12/31/18
Palo Alto Investors LP 5,262,263 8.65 576,911 3/31/19
Consonance Capital Management LP 5,158,884 8.48 348,806 3/31/19
Ridgeback Capital Management, L.P. 3,945,200 6.48 1,213,075 12/31/18
BlackRock Institutional Trust Company, N.A. 3,771,165 6.20 -86,697 3/31/19
Emerald Advisers LLC 2,884,569 4.74 54,659 3/31/19
Millennium Management LLC 2,719,714 4.47 2,272,107 3/31/19
The Vanguard Group, Inc. 2,614,272 4.30 885,385 3/31/19
Candriam Belgium S.A. 1,916,778 3.15 50,000 5/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Candriam Equities L Biotechnology 1,815,500 2.98 -- 5/31/19
Vanguard Total Stock Market Index Fund 1,750,506 2.88 -- 6/30/19
iShares Russell 2000 ETF 1,204,457 1.98 198,407 6/30/19
Fidelity Select Biotechnology Portfolio 1,102,000 1.81 -284,300 5/31/19
Emerald Growth Fund 833,486 1.37 -- 5/31/19
Wellington Global Healthcare Equity Fund 767,000 1.26 285,167 12/31/17
Vanguard Extended Market Index Fund 710,246 1.17 3,092 6/30/19
iShares NASDAQ Biotechnology ETF 608,427 1.00 -13,200 6/30/19
iShares Russell 2000 Growth ETF 509,778 0.84 131,080 6/30/19
Hartford Healthcare Fund 457,189 0.75 -- 5/31/19

* Insider values reflect direct beneficial ownership.

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