Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 169 648.12 95.85 60,121,868
Mutual Fund 328 285.62 27.40 17,186,943
Insider 7 20.93 2.22 1,391,371

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 120 251.40 21.13 13,268,814
Sellers 80 -230.58 21.65 -13,596,303
Net 20.82 0.52 -327,489

Concentration

Value ($MM) % O/S Shares
Total Inst. 1,369.86 118.06 74,066,585
Top 10 Inst. 781.41 68.22 42,778,984
Top 20 Inst. 1,038.54 89.58 56,192,230
Top 50 Inst. 1,271.94 109.51 68,703,186

Style

Holders Value ($MM) % Inst Shares Shares
Growth 50 113.94 9.49 5,958,854
Aggressive Growth 4 5.29 0.44 276,198
Core Growth 37 74.22 6.19 3,886,620
Growth 9 34.43 2.86 1,796,036
Income 4 3.37 0.28 177,159
Income Value 1 3.20 0.27 167,155
Yield 3 0.16 0.02 10,004
Index 26 253.33 21.28 13,362,034
Other 74 759.05 66.53 41,719,474
Broker Dealer 15 18.42 1.53 960,915
GARP 18 95.69 8.12 5,097,400
Hedge Fund 36 475.14 42.78 26,803,699
Specialty 1 0.34 0.03 17,909
VC Private Equity 3 157.53 13.09 8,217,651
Sector Specific 1 11.92 0.99 621,900
Value 23 40.23 3.44 2,156,938
Core Value 18 33.82 2.90 1,822,643
Deep Value 5 6.41 0.53 334,295

Location: Global Region

Holders % O/S Shares Share Value
North America 180 104.00 65,245,240 1,203,230,880
Europe 30 13.10 8,227,598 157,139,124
Middle East 1 0.53 330,000 6,326,100
Asia / Pacific 8 0.46 289,443 3,522,128
Latin America -- -- -- --

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Consonance Capital Management LP 6,127,434 9.76 290,000 12/31/19
Avoro Capital Advisors LLC 5,900,000 9.40 -150,000 12/31/19
Chione, Ltd. 5,695,499 9.07 -1,935,768 12/31/19
Palo Alto Investors LP 4,595,001 7.32 -247,149 12/31/19
BlackRock Institutional Trust Company, N.A. 4,369,082 6.96 82,494 12/31/19
Ridgeback Capital Management, L.P. 3,945,200 6.37 1,213,075 12/31/18
Adage Capital Management, L.P. 3,787,000 6.03 -213,000 12/31/19
State Street Global Advisors (US) 3,228,366 5.14 79,850 12/31/19
The Vanguard Group, Inc. 2,765,891 4.41 21,330 12/31/19
D. E. Shaw & Co., L.P. 2,365,511 3.77 984,484 12/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 1,966,527 3.13 12,584 1/31/20
Vanguard Total Stock Market Index Fund 1,484,946 2.36 2,461 1/31/20
iShares Russell 2000 ETF 1,273,271 2.03 -80,280 1/31/20
Vanguard Extended Market Index Fund 775,700 1.24 14,372 1/31/20
Fidelity Select Biotechnology Portfolio 631,798 1.01 179,498 12/31/19
Biotech Growth Trust PLC 621,900 0.99 -444,000 11/30/19
Candriam Equities L Biotechnology 615,950 0.98 -85,000 12/31/19
iShares NASDAQ Biotechnology ETF 567,269 0.90 -6,968 1/31/20
iShares Russell 2000 Growth ETF 549,168 0.87 7,795 1/31/20
DFA U.S. Small Cap Portfolio 493,510 0.79 -- 10/31/19

* Insider values reflect direct beneficial ownership.

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