Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 218 1,436.20 102.47 74,928,515
Mutual Fund 219 234.00 16.66 12,141,901
Insider 7 22.41 1.90 1,389,714

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 127 325.67 23.23 16,986,125
Sellers 96 -116.36 8.30 -6,068,530
Net 209.31 14.93 10,917,595

Concentration

Value ($MM) % O/S Shares
Total Inst. 1,569.32 112.28 82,103,936
Top 10 Inst. 861.08 61.37 44,875,406
Top 20 Inst. 1,209.61 86.23 63,055,666
Top 50 Inst. 1,473.45 105.34 77,025,811

Style

Holders Value ($MM) % Inst Shares Shares
Growth 58 221.41 15.82 11,564,917
Aggressive Growth 4 4.09 0.29 213,547
Core Growth 42 155.89 11.10 8,118,296
Growth 12 61.43 4.42 3,233,074
Income 4 5.36 0.39 281,781
Income Value 1 3.31 0.24 172,217
Yield 3 2.05 0.15 109,564
Index 27 270.09 19.24 14,066,585
Other 70 832.20 59.31 43,367,424
Broker Dealer 17 29.40 2.10 1,533,019
GARP 20 122.04 8.75 6,395,791
Hedge Fund 30 502.23 35.76 26,145,099
Specialty 1 0.59 0.04 30,509
VC Private Equity 2 177.94 12.67 9,263,006
Sector Specific -- -- -- --
Value 26 37.26 2.72 1,986,569
Core Value 21 32.23 2.36 1,724,481
Deep Value 5 5.03 0.36 262,088

Location: Global Region

Holders % O/S Shares Share Value
North America 181 97.45 71,258,438 1,361,751,792
Europe 34 13.85 10,124,764 193,929,275
Middle East 1 0.75 550,000 10,565,500
Asia / Pacific 10 0.11 80,526 1,541,267

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Consonance Capital Management LP 7,180,700 9.82 1,053,266 3/31/20
Avoro Capital Advisors LLC 7,000,000 9.57 1,100,000 3/31/20
Chione, Ltd. 5,695,499 7.79 -1,935,768 12/31/19
BlackRock Institutional Trust Company, N.A. 4,436,499 6.07 67,417 3/31/20
Palo Alto Investors LP 4,299,901 5.88 -295,100 3/31/20
Adage Capital Management, L.P. 3,723,532 5.09 -63,468 3/31/20
Janus Henderson Investors 3,252,828 4.45 3,246,852 3/31/20
The Vanguard Group, Inc. 3,248,459 4.44 482,568 3/31/20
State Street Global Advisors (US) 3,247,487 4.44 19,121 3/31/20
Frontier Capital Management Company, LLC 2,790,501 3.82 951,061 6/30/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 3,069,332 4.20 930,781 6/30/20
Vanguard Total Stock Market Index Fund 1,749,201 2.39 -5,888 6/30/20
iShares Russell 2000 ETF 1,468,266 2.01 -2,972 7/31/20
Janus Henderson Global Life Sciences Fund (US) 1,190,843 1.63 1,190,843 3/31/20
Vanguard Extended Market Index Fund 937,318 1.28 7,992 6/30/20
ACAP Strategic Fund 800,163 1.09 800,163 3/31/20
iShares NASDAQ Biotechnology ETF 759,286 1.04 14,418 7/31/20
Fidelity Select Biotechnology Portfolio 675,410 0.92 -208,700 6/30/20
iShares Russell 2000 Growth ETF 656,363 0.90 -3,200 7/31/20
T. Rowe Price New Horizons Fund 600,563 0.82 145,501 6/30/20

* Insider values reflect direct beneficial ownership.

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