Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 162 654.73 99.32 62,255,658
Mutual Fund 317 299.28 28.59 17,921,742
Insider 7 23.12 2.22 1,391,371

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 90 195.41 29.28 18,383,248
Sellers 83 -157.59 24.91 -15,639,737
Net 37.83 4.37 2,743,511

Concentration

Value ($MM) % O/S Shares
Total Inst. 749.35 113.87 71,278,296
Top 10 Inst. 465.60 72.65 45,415,231
Top 20 Inst. 606.77 93.03 58,207,915
Top 50 Inst. 716.86 109.09 68,284,232

Style

Holders Value ($MM) % Inst Shares Shares
Growth 38 76.96 12.64 7,893,944
Aggressive Growth 4 1.82 0.24 147,858
Core Growth 28 40.98 6.69 4,198,844
Growth 6 34.16 5.71 3,547,242
Income 2 1.71 0.27 168,452
Income Value 1 1.53 0.25 159,414
Yield 1 0.17 0.01 9,038
Index 23 125.75 20.68 12,982,910
Other 53 403.98 59.49 37,299,061
Broker Dealer 15 8.96 1.48 931,126
GARP 16 63.02 8.03 5,038,317
Hedge Fund 18 262.86 38.54 24,141,592
Specialty 1 0.17 0.03 17,481
VC Private Equity 2 58.73 9.72 6,104,645
Sector Specific 1 10.25 1.70 1,065,900
Value 21 30.16 4.10 2,569,081
Core Value 17 24.18 3.27 2,050,634
Deep Value 4 5.98 0.83 518,447

Location: Global Region

Holders % O/S Shares Share Value
North America 133 97.50 61,113,326 637,030,835
Europe 29 15.92 9,889,159 109,074,439
Asia / Pacific 7 0.44 274,373 3,235,380
Latin America 1 -- 1,438 13,834

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Chione, Ltd. 7,631,267 12.32 -761,872 12/31/18
Avoro Capital Advisors LLC 6,050,000 9.64 6,050,000 9/30/19
Consonance Capital Management LP 5,837,434 9.30 34,207 9/30/19
Palo Alto Investors LP 4,842,150 7.71 -420,113 9/30/19
BlackRock Institutional Trust Company, N.A. 4,286,588 6.83 155,512 9/30/19
Adage Capital Management, L.P. 4,000,000 6.37 2,300,000 11/8/19
Ridgeback Capital Management, L.P. 3,945,200 6.37 1,213,075 12/31/18
State Street Global Advisors (US) 3,148,516 5.01 2,028,790 9/30/19
Emerald Advisers LLC 2,929,515 4.73 77,882 9/30/19
The Vanguard Group, Inc. 2,744,561 4.37 -239,301 9/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 1,953,943 3.11 9,329 12/31/19
Vanguard Total Stock Market Index Fund 1,482,485 2.36 374 12/31/19
iShares Russell 2000 ETF 1,353,551 2.16 22,504 12/31/19
Biotech Growth Trust PLC 1,065,900 1.70 -- 10/31/19
Emerald Growth Fund 810,716 1.29 -61,270 11/30/19
Vanguard Extended Market Index Fund 761,328 1.21 11,449 12/31/19
Candriam Equities L Biotechnology 700,950 1.12 -200,000 11/30/19
iShares NASDAQ Biotechnology ETF 574,237 0.91 -82,075 12/31/19
iShares Russell 2000 Growth ETF 541,373 0.86 10,638 12/31/19
DFA U.S. Small Cap Portfolio 493,510 0.79 -- 10/31/19

* Insider values reflect direct beneficial ownership.

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