Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 155 427.19 87.59 54,424,946
Mutual Fund 303 175.79 28.47 17,649,125
Insider 7 20.66 2.21 1,386,371

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 80 142.55 28.07 17,623,363
Sellers 69 -105.08 18.88 -11,852,533
Net 37.47 9.19 5,770,830

Concentration

Value ($MM) % O/S Shares
Total Inst. 594.42 108.31 67,467,116
Top 10 Inst. 370.83 67.97 42,306,385
Top 20 Inst. 483.30 88.76 55,273,480
Top 50 Inst. 572.92 104.15 64,876,235

Style

Holders Value ($MM) % Inst Shares Shares
Growth 35 71.50 12.43 7,750,111
Aggressive Growth 2 0.13 0.04 21,948
Core Growth 27 38.65 6.73 4,218,042
Growth 6 32.72 5.66 3,510,121
Income 2 1.64 0.27 168,746
Income Value 1 1.53 0.25 159,414
Yield 1 0.11 0.01 9,332
Index 22 89.45 17.43 10,880,711
Other 52 226.91 51.41 31,848,810
Broker Dealer 14 3.85 0.81 506,735
GARP 14 37.63 7.04 4,370,879
Hedge Fund 22 166.41 38.44 23,805,240
Specialty 1 0.17 0.03 17,481
Sector Specific 1 18.86 5.08 3,148,475
Value 21 27.29 4.06 2,538,564
Core Value 17 22.18 3.20 2,006,967
Deep Value 4 5.11 0.85 531,597

Location: Global Region

Holders % O/S Shares Share Value
North America 128 85.15 52,927,518 421,226,317
Europe 27 16.54 10,247,540 96,111,942
Asia / Pacific 7 0.43 266,088 2,010,507
Latin America 1 -- 1,438 8,614

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Chione, Ltd. 7,631,267 12.32 -761,872 12/31/18
Consonance Capital Management LP 5,837,434 9.30 34,207 9/30/19
Palo Alto Investors LP 5,262,263 8.50 -- 6/30/19
BlackRock Institutional Trust Company, N.A. 4,286,588 6.83 155,512 9/30/19
Ridgeback Capital Management, L.P. 3,945,200 6.37 1,213,075 12/31/18
Millennium Management LLC 3,372,566 5.45 3,299,911 7/22/19
State Street Global Advisors (US) 3,148,516 5.01 2,028,790 9/30/19
OrbiMed Advisors, LLC 3,148,475 5.08 2,436,875 6/30/19
Emerald Advisers LLC 2,929,515 4.73 77,882 9/30/19
The Vanguard Group, Inc. 2,744,561 4.37 -239,301 9/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 1,844,187 2.94 -87,734 10/31/19
Vanguard Total Stock Market Index Fund 1,481,507 2.36 -268,999 9/30/19
iShares Russell 2000 ETF 1,309,935 2.09 -25,984 10/31/19
Candriam Equities L Biotechnology 950,950 1.51 -- 9/30/19
Emerald Growth Fund 871,986 1.39 38,500 9/30/19
Fidelity Select Biotechnology Portfolio 790,200 1.26 -163,100 9/30/19
Vanguard Extended Market Index Fund 736,113 1.17 7,018 9/30/19
Wellington Global Healthcare Equity Fund 703,401 1.12 -38,145 8/31/19
iShares NASDAQ Biotechnology ETF 587,943 0.94 -21,984 10/31/19
iShares Russell 2000 Growth ETF 520,216 0.83 -6,424 10/31/19

* Insider values reflect direct beneficial ownership.

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