Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 210 1,202.66 100.26 63,004,356
Mutual Fund 335 275.31 26.23 16,830,765
Insider 8 28.10 2.00 1,419,363

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 116 247.16 17.78 12,900,739
Sellers 80 -304.76 24.08 -17,471,042
Net -57.60 6.30 -4,570,303

Concentration

Value ($MM) % O/S Shares
Total Inst. 1,339.46 110.91 70,093,522
Top 10 Inst. 787.83 65.07 41,096,790
Top 20 Inst. 1,017.24 84.13 53,064,291
Top 50 Inst. 1,243.93 102.59 64,815,280

Style

Holders Value ($MM) % Inst Shares Shares
Growth 49 113.15 9.43 5,927,411
Aggressive Growth 3 4.49 0.37 234,302
Core Growth 37 74.08 6.18 3,886,290
Growth 9 34.58 2.87 1,806,819
Income 4 3.37 0.28 177,159
Income Value 1 3.20 0.27 167,155
Yield 3 0.16 0.01 10,004
Index 26 255.02 21.20 13,316,380
Other 73 723.96 60.30 37,876,002
Broker Dealer 15 18.42 1.53 960,915
GARP 18 97.56 8.25 5,199,128
Hedge Fund 35 438.18 36.40 22,858,499
Specialty 1 0.34 0.03 17,909
VC Private Equity 3 157.53 13.09 8,217,651
Sector Specific 1 11.92 0.99 621,900
Value 23 40.05 3.43 2,157,138
Core Value 18 33.66 2.90 1,822,843
Deep Value 5 6.40 0.53 334,295

Location: Global Region

Holders % O/S Shares Share Value
North America 179 97.10 61,158,427 1,171,207,361
Europe 31 12.86 8,341,158 158,891,880
Middle East 1 0.53 330,000 6,326,100
Asia / Pacific 8 0.46 289,633 3,523,520
Latin America -- -- -- --

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Consonance Capital Management LP 6,127,434 9.76 290,000 12/31/19
Avoro Capital Advisors LLC 5,900,000 9.40 -150,000 12/31/19
Chione, Ltd. 5,695,499 8.69 -1,935,768 12/31/19
Palo Alto Investors LP 4,595,001 7.32 -247,149 12/31/19
BlackRock Institutional Trust Company, N.A. 4,369,082 6.96 82,494 12/31/19
Adage Capital Management, L.P. 3,787,000 6.03 -213,000 12/31/19
State Street Global Advisors (US) 3,228,366 5.14 79,850 12/31/19
The Vanguard Group, Inc. 2,765,891 4.41 21,330 12/31/19
D. E. Shaw & Co., L.P. 2,365,511 3.77 984,484 12/31/19
Delphi Management Partners VIII, L.L.C (Sibling) 2,263,006 3.60 2,263,006 12/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 1,934,305 2.67 -32,222 2/29/20
Vanguard Total Stock Market Index Fund 1,553,492 2.14 68,546 2/29/20
iShares Russell 2000 ETF 1,294,275 1.78 21,004 2/29/20
Vanguard Extended Market Index Fund 774,978 1.07 -722 2/29/20
Fidelity Select Biotechnology Portfolio 631,798 0.87 -- 1/31/20
Biotech Growth Trust PLC 621,900 0.86 -- 12/31/19
Candriam Equities L Biotechnology 615,950 0.85 -85,000 12/31/19
iShares NASDAQ Biotechnology ETF 562,669 0.78 -4,600 2/29/20
iShares Russell 2000 Growth ETF 539,520 0.74 -9,648 2/29/20
DFA U.S. Small Cap Portfolio 493,510 0.68 -- 10/31/19

* Insider values reflect direct beneficial ownership.

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