Ran Frenkel RPh

Chief Development Operations Officer

Mr. Frenkel was appointed Executive Vice President, Worldwide Development Operations of Karyopharm in October, 2014. Mr. Frenkel is responsible for managing the subsidiary, Karyopharm Europe GmbH, which will provide the corporate structure necessary to support Karyopharm's expanded clinical and regulatory activities in Europe. In addition, Frenkel is responsible for the corporate global development operations across the entire portfolio. In this capacity Frenkel is managing the clinical departments including Clinical Operations, Product Leadership, Quality, Regulatory Affairs, Medical Writing, Medical & Scientific Affairs and Biology.

Mr. Frenkel has more than 20 years of experience in the international biopharmaceutical industry encompassing clinical, regulatory, business development and commercial operations activities.

Prior to joining Karyopharm Europe GmbH, Mr. Frenkel held a number of senior management roles in Europe, Israel and the United States, most recently as Managing Director EMEA for Clinipace Worldwide, an international clinical research organization, where he had responsibility for the overall management of the organization in Europe, the Middle East and Africa.

Prior to joining Clinipace Worldwide, Mr. Frenkel established and managed the Israeli office of PFC Pharma Focus AG, which was acquired by Clinipace in 2011, and he held the position of Managing Director at Actelion Pharmaceuticals with responsibility for all science and business affairs of the company in Israel.